Frontier Deal Flow is a monthly curated database report within 22nd Century Frontier, connecting high-quality companies with thousands of active investors, including angels, VC funds, family offices, institutional investors, and strategic partners.
It is designed to surface signal early and improve how capital is matched with emerging opportunities.
The 22nd Century Frontier Show 🎙️
Conversations with the founders, investors, and executives shaping what comes next.
Episode 1 features Guy Kawasaki, from Apple’s original Macintosh team to Canva and venture capital.
Episode 1 premieres 6 October at 6 PM London / 1 PM New York / 10 AM San Francisco.
We’ll explore:
• What makes a product truly unique in the age of AI
• How companies turn customers into believers
• What he’d look for if starting over in Silicon Valley
• What it really takes to invest in an unproven startup
🎬 Subscribe on YouTube to follow the show and make sure you don’t miss Episode 1.
Table of Contents
1. Issue Snapshot
For this Frontier Deal Flow issue features 4 companies across 2 countries.
This month’s cohort spans Pre-Seed and Seed, with a strong concentration in AI-driven businesses across financial services, healthcare, commerce, and media.
A few of the companies in this issue are working on:
AI agents and deterministic underwriting for private-market capital allocation
agentic video infrastructure turning live events into personalized, distributed content
a social media marketplace using patent-pending incentives to reward measurable real-world impact
AI-powered adaptive diabetes care connecting personalized patient support with health-system workflows
…and more companies building at the intersection of AI, finance, healthcare, media, and emerging technology.
By the numbers
5 submissions received
4 companies featured
2 countries represented
Geographic mix:
North America 100%Most common stages:
Pre-Seed, Seed
(Pre-Seed 50% | Seed 50%)AI exposure:
AI & Machine Learning appears in 75% of the featured cohortSector spread:
AI & Machine Learning, FinTech & InsurTech, HealthTech, E-Commerce, Media, Entertainment & Gaming
2. What We Cover
Each featured company includes a structured profile designed to help investors review opportunities quickly and efficiently.
Required fields
Company name
Website
Country
Sector
Stage
Contact information
Investment deck
Investor signals
Amount raising
Traction summary
Revenue or growth metrics
Previous investors
Fundraising deadline
One-line pitch
3. How Access Works
Frontier Deal Flow is shared in two formats.
Paid subscribers receive the full report, including:
company contact details
downloadable pitch decks
full investor signals and metrics
This version is available immediately below, giving investors time to review the companies and reach out directly to the ones they are interested in.
A limited version will be released two weeks later, and shared with the broader readership.
This version will include the company list, but without contact details, decks, investor signals, or metrics.
The goal is to maintain strong signal for investors while still showcasing frontier innovation to the wider community.
4. Submit For The Next Issue
Founders who would like to be included in Frontier Deal Flow: October 2026, published on 2 November, can submit their company here:
Submissions are completely FREE.
5. Access The Full Report
Subscribe to unlock access to:
✅ All premium resources
✅ Full archive
✅ Future Frontier Deal Flow issues
And more.
